The network's former executives Tony DiSanto and Liz Gateley are overseeing the effort, with a search for a writer currently under way.
The network is developing a TV series adaptation of Wes Craven and Kevin Williamson's horror franchise, sources confirmed to The Hollywood Reporter.
As first reported by TV Line, former MTV executives Tony DiSanto (The Hills, Teen Wolf, Teen Mom) and Liz Gateley (The Hard Times of RJ Berger) are on board to executive produce the project, with a search currently under way to find a writer to pen the project.
What role Scream director Craven and screenwriter Williamson would have with the project has yet to be determined.
Since debuting in 1996, the franchise -- which stars Neve Campbell as Sidney along with Courteney Cox as investigative reporter Gale Weathers and David Arquette as loyal lawman Dewey -- has spawned three sequels. The franchise has grossed more than $330 million worldwide.
Williamson, meanwhile, already has two series set for the 2012-13 television season: the CW's Vampire Diaries and Fox's Kevin Bacon serial killer drama The Following, which was picked up to series in May.
The project comes as the young-skewing network has found success on the scripted side with another feature film-to-series TV adaptation in Teen Wolf, which was based on the 1980s movies that originally starred Michael J. Fox. The werewolf drama returned for a second season Sunday night.