Creators and stars James Corden and Ruth Jones will serve as executive producers on the American project, as will I Just Want My Pants Back writer David Rosen, who will work on the script.
Fox's version of the BBC comedy will focus on the key life moments of the title characters as they try to maintain their relationship while combining their families' lives, according to The Hollywood Reporter.
Corden and Jones, who starred in the UK series as Smithy and Nessa, will not have on-screen roles in the Fox project.
BBC Worldwide Productions and Sony Pictures TV are producing the show with the company behind the UK series, Baby Cow Productions. Henry Normal, executive producer of the UK version, will fulfil the same role on the US remake.
ABC previously attempted to adapt the series in 2009 with Stacy Traub and Hayes Jackson as writers.
Gavin & Stacey, which aired on BBC America in the States, ran for three series and a Christmas special. Both Jones and Corden have ruled out making more UK episodes in the near future.
