The Argo director is to present the cheque to a youth activist at the annual gala, which is taped on Sunday (August 12) in Santa Monica, CA.
Affleck is also nominated in the 'Do Something Facebook' category for his work with the Eastern Congo Initiative. The group seeks to improve political and social conditions in the African nation.
Selena Gomez, Taylor Swift, Matt Damon, Amy Poehler and Channing Tatum are among other celebrity nominees.
A full list of the VH1 Do Something Awards 2012 nominee is available here.
New Girl's Jake Johnson, Max Greenfield and Lamorne Morris host the VH1 Do Something Awards 2012, airing Tuesday, August 21 on VH1 at 9/8c.
